The role and intrinsic connection of cellular senescence and cell death in inflammatory bowel disease

The role and intrinsic connection of cellular senescence and cell death in inflammatory bowel disease

Blog Article

Cellular senescence in the intestine can induce cell death, which extends beyond the mere clearance valhalla axys of senescent cells.This phenomenon is prevalent in inflammatory and immune-related diseases, particularly in inflammatory bowel disease (IBD).IBD is characterized by recurrent and chronic intestinal inflammation, with the occurrence and development of the disease being influenced by multiple factors, including genetics, environment, lifestyle, intestinal immunity, and gut microbiota.

Chronic intestinal inflammation drives aging of the IBD immune system, reducing its efficiency and impairing the clearance of senescent cells.The disruption of cell death regulation and the interplay between cell death and cellular senescence contribute to disease progression in IBD, with inflammaging and immunosenescence here playing the key role in this process.However, the mechanisms underlying the interplay between cell death and cellular senescence in the context of IBD remain unclear.

Therefore, this paper comprehensively reviews the impact of cellular death and cellular senescence on intestinal aging in IBD, emphasizing the exploration of their potential interrelationships.